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Alegre, Maria-Luisa
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overview My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.
One or more keywords matched the following items that are connected to Alegre, Maria-Luisa
Item TypeName
Concept Adjuvants, Immunologic
Concept Binding Sites, Antibody
Concept Alleles
Concept Amino Acid Sequence
Concept Antigens, Surface
Concept Antibody Specificity
Concept Base Sequence
Concept Binding Sites
Concept Genes, Immunoglobulin
Concept Immune System
Concept Drug Synergism
Concept Graft Survival
Concept Immune Sera
Concept Genes, MHC Class I
Concept Lymphatic System
Concept Mice, Inbred Strains
Concept Molecular Sequence Data
Concept Heat-Shock Proteins
Concept Major Histocompatibility Complex
Concept Splenomegaly
Concept Freund's Adjuvant
Concept Sequence Homology, Nucleic Acid
Concept Intestine, Small
Concept Solubility
Concept Salmonella typhimurium
Concept Sarcoidosis
Concept Staphylococcal Skin Infections
Concept Staphylococcus epidermidis
Concept Skin
Concept Societies, Medical
Concept Staphylococcal Infections
Concept Succinimides
Concept Symbiosis
Concept Specific Pathogen-Free Organisms
Concept Sequence Homology, Amino Acid
Concept Hematopoietic Stem Cell Transplantation
Concept B-Lymphocyte Subsets
Concept Trimethoprim, Sulfamethoxazole Drug Combination
Concept Lupus Erythematosus, Systemic
Concept Skin Diseases, Bacterial
Concept Stem Cell Transplantation
Concept Case-Control Studies
Concept T-Lymphocyte Subsets
Concept Genes, Reporter
Concept Soft Tissue Infections
Concept src-Family Kinases
Concept Transgenes
Concept Calcium Signaling
Concept src Homology Domains
Concept Adaptor Protein Complex mu Subunits
Concept Biological Specimen Banks
Concept Oligonucleotide Array Sequence Analysis
Concept STAT3 Transcription Factor
Concept NF-kappa B p52 Subunit
Concept Salmonella Infections, Animal
Concept Severity of Illness Index
Concept Interleukin Receptor Common gamma Subunit
Concept Glycogen Synthase Kinase 3
Concept Sex Factors
Concept Skin Neoplasms
Concept Interleukin-2 Receptor alpha Subunit
Concept Spleen
Concept Staphylococcus aureus
Concept Adaptor Proteins, Signal Transducing
Concept NK Cell Lectin-Like Receptor Subfamily K
Concept Survival Analysis
Concept Skin Transplantation
Concept Lymphocyte Subsets
Concept Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Concept MAP Kinase Signaling System
Concept Bariatric Surgery
Concept STAT1 Transcription Factor
Concept STAT5 Transcription Factor
Concept Intracellular Signaling Peptides and Proteins
Concept STAT4 Transcription Factor
Concept STAT6 Transcription Factor
Concept Cell Survival
Concept Drug Administration Schedule
Concept Follow-Up Studies
Concept Prospective Studies
Concept Retrospective Studies
Concept Signal Transduction
Concept Granulocyte-Macrophage Colony-Stimulating Factor
Concept Mice, SCID
Concept NF-kappa B p50 Subunit
Concept CARD Signaling Adaptor Proteins
Concept Interleukin-7 Receptor alpha Subunit
Concept Genetic Loci
Academic Article Bioactivity of recombinant feline interleukin-2 on human and feline leukocytes.
Academic Article Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
Academic Article Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression.
Academic Article Tissue distribution, regulation and intracellular localization of murine CD1 molecules.
Academic Article Regulation of surface and intracellular expression of CTLA4 on mouse T cells.
Academic Article Impaired negative selection in CD28-deficient mice.
Academic Article Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
Academic Article Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Academic Article Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
Academic Article Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
Academic Article Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
Academic Article Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.
Academic Article Secondary lymphoid organs are important but not absolutely required for allograft responses.
Academic Article Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts.
Academic Article TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism.
Academic Article GATA-3: an unexpected regulator of cell lineage determination in skin.
Academic Article Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial.
Academic Article Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Academic Article Modulation of tryptophan catabolism by regulatory T cells.
Academic Article CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Academic Article Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration.
Academic Article Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice.
Academic Article Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL.
Academic Article Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Academic Article Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
Academic Article Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues.
Academic Article Role of natural killer cell subsets in cardiac allograft rejection.
Academic Article Cellular mechanisms underlying acute graft rejection: time for reassessment.
Academic Article Overexpression of program death-1 in T cells has mild impact on allograft survival.
Academic Article Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.
Academic Article Toll-like receptor signaling in transplantation.
Academic Article Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling.
Academic Article The balance of immune responses: costimulation verse coinhibition.
Academic Article Peripheral survival of naïve CD8+ T cells.
Academic Article Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.
Academic Article The multiple facets of toll-like receptors in transplantation biology.
Academic Article TLR signals promote IL-6/IL-17-dependent transplant rejection.
Academic Article Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome.
Academic Article T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Academic Article IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article The inside story of dendritic cell immunotherapy.
Academic Article Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations.
Academic Article Role of T cell-nuclear factor ?B in transplantation.
Academic Article The impact of infection and tissue damage in solid-organ transplantation.
Academic Article Literature watch implications for transplantation. The anti-infectious role of the IL-17 pathway.
Academic Article High TCR stimuli prevent induced regulatory T cell differentiation in a NF-?B-dependent manner.
Academic Article TLR engagement prevents transplantation tolerance.
Academic Article An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.
Academic Article Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.
Academic Article Sequence and functional characterization of feline interleukin 2.
Academic Article Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells.
Academic Article Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Academic Article A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.
Academic Article Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model.
Academic Article Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.
Academic Article Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells.
Academic Article CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Academic Article Role of T-cell-specific nuclear factor ?B in islet allograft rejection.
Academic Article T cell receptor/CARMA1/NF-?B signaling controls T-helper (Th) 17 differentiation.
Academic Article Expression and function of CTLA-4 in Th1 and Th2 cells.
Academic Article CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease.
Academic Article CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Academic Article Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells.
Academic Article Nephrogenic systemic fibrosis associated with stromal and vascular calcification, report of two cases.
Academic Article Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Award or Honor Receipt Basic Science Investigator Award
Award or Honor Receipt Leif B. Sorenson Faculty Research Award
Award or Honor Receipt Basic Science Career Development Award
Award or Honor Receipt Intensive Care Competence Summa Cum Laude
Award or Honor Receipt MD Summa Cum Laude
Academic Article The microbiota, the immune system and the allograft.
Academic Article Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A.
Academic Article IFN-?: The Dr. Jekyll and Mr. Hyde of immunology?
Academic Article Transplantation tolerance and its outcome during infections and inflammation.
Academic Article Lessons and limits of mouse models.
Academic Article Microbes and allogeneic transplantation.
Academic Article Basal NF-?B controls IL-7 responsiveness of quiescent naïve T cells.
Academic Article I spy alloreactive T cells.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage.
Academic Article T-cell regulation by CD28 and CTLA-4.
Academic Article The interplay between the intestinal microbiota and the immune system.
Academic Article Spontaneous restoration of transplantation tolerance after acute rejection.
Academic Article Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection.
Academic Article Germ Warfare.
Academic Article High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Academic Article Tumor-associated fibroblasts predominantly come from local and not circulating precursors.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection.
Academic Article Impact of Staphylococcus aureus USA300 Colonization and Skin Infections on Systemic Immune Responses in Humans.
Academic Article Standardizing Mouse Models to Account for Host-Microbial Interactions.
Academic Article Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
Academic Article Natural killer cell subsets in allograft rejection and tolerance.
Academic Article Long-term Maintenance of Sterility Following Skin Transplantation in Germ-free Mice.
Academic Article Super-MANF to the Rescue: Immunomodulation Improves Retinal Repair and Regenerative Cell Therapy.
Academic Article Erosion of Transplantation Tolerance After Infection.
Academic Article Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice.
Academic Article The Multiple Molecular Paths of Antibody Suppression by TFR Cells.
Academic Article The Tpm Subset of the CD8+ T Cell Memory Family.
Academic Article Select Effects of IL-13 in Driving Tissue Repair and Fibrosis.
Academic Article Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article The Bugs That Keep Us Safe.
Academic Article Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice.
Academic Article Sweet T Cell Dysfunction.
Academic Article The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
Academic Article Gut microbes contribute to variation in solid organ transplant outcomes in mice.
Academic Article Novel Role of Calcineurin Inhibitors in Curbing T Cells' Sweet Tooth.
Academic Article The Unbearable Lightness of Breathing.
Academic Article Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance.
Academic Article T Cell Receptor-Regulated TGF-ß Type I Receptor Expression Determines T Cell Quiescence and Activation.
Academic Article Predicting TCR specificity?
Academic Article Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients.
Academic Article Stealing Tregs' Identity (by Deleting NF-?B).
Academic Article The Adaptive NK Cell Response.
Award or Honor Receipt Paul S. Russell Visiting Professor
Academic Article Thymic regulatory T cells arise via two distinct developmental programs.
Academic Article B cells, CMV, and stem cell transplant.
Academic Article Exercise increases skin graft resistance to rejection.
Academic Article Retrospective Identification of a Broad IgG Repertoire Differentiating Patients With S. aureus Skin and Soft Tissue Infections From Controls.
Academic Article Outstanding questions in transplantation: An introduction to this minireview series.
Academic Article Fifty Shades of Tolerance: Beyond a Binary Tolerant/Non-Tolerant Paradigm.
Academic Article Mouse microbiomes: overlooked culprits of experimental variability.
Award or Honor Receipt Established Investigator Award
Grant Impact of Microbiota on Alloimmune Responses in Transplantation
Grant Infections and the Stability of Transplantation Tolerance
Grant The microbiota and allograft rejection: novel investigations into the consequences of obesity
Academic Article Lymph node segregation for tolerance or inflammation.
Academic Article Skin-restricted commensal colonization accelerates skin graft rejection.
Academic Article Fibroblasts can have subsets too!
Academic Article Impact of the microbiota on solid organ transplant rejection.
Academic Article Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.
Academic Article Pathogenic Bhlhe40+ GM-CSF+ CD4+ T cells promote indirect alloantigen presentation in the GI tract during GVHD.
Academic Article The First International Transplant Science (ITS) Meeting.
Academic Article Giving effector/memory T cells a new (suppressive) purpose.
Academic Article Exploiting immunometabolism and T cell function for solid organ transplantation.
Academic Article Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination.
Academic Article The First ITS Meeting.
Academic Article Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells.
Academic Article The anti-inflammatory function of the apoptotic secretome.
Academic Article Can Diet Induce Transplantation Tolerance?
Academic Article Introduction to this Cellular Immunology issue on new advances in solid organ transplantation immunology.
Academic Article The COVID-19 pandemic: A community approach.
Award or Honor Receipt Elected Fellow
Award or Honor Receipt Member, TTT study section
Award or Honor Receipt Section Editor
Award or Honor Receipt Board of Directors
Award or Honor Receipt Member, AITC study section
Award or Honor Receipt Section Editor
Award or Honor Receipt Chair, Community of Basic Scientists
Academic Article Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice.
Academic Article Influence of the microbiome on solid organ transplant survival.
Academic Article Restored TDCA and valine levels imitate the effects of bariatric surgery.
Academic Article Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival.
Academic Article Toward an understanding of allogeneic conflict in pregnancy and transplantation.
Academic Article Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation.
Academic Article Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance.
Academic Article Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants.
Academic Article Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival.
Academic Article Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival.
Grant Role of NF-kB Activation in Acute Allograft Rejection
Grant Mechanisms of TLR-mediated prevention of transplantation tolerance
Grant Epidemic CA-MRSA: Molecular Epidemiology and Immunology
Grant Role of NF-kB Activation in Acute Allograft Rejection
Grant NF-kappaBeta activation T cell function/graft rejection
Academic Article Pregnancy programs epigenetic and transcriptional exhaustion in memory CD8+ T cells.
Academic Article Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice.
Academic Article Methods to Study TLRs in Transplantation.
Academic Article Biological Time Travel: Tracking the Journey of Alloreactive T Cells Through Longitudinal Biobanking.
Academic Article Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection.
Academic Article Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice.
Academic Article Coordinated elimination of bacterial taxa optimally attenuates alloimmunity and prolongs allograft survival.
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